It's been circulating in the news recently that antibody injection which is used as a treatment for people with chronic diseases like cancer, psoriasis, arthritis, and Crohn's disease; is also a rising treatment for severe cases of COVID-19. But, the manufacturing procedure for these antibodies is time-consuming and costly which hinders the production to most patients. 

In recent research published in Biotechnology Progress conducted by Andrew Zydney, Bayard D. Kunkle Chair, and professor of chemical engineering at Penn State, a new method in manufacturing antibodies was established which could drive down the cost for production.

Applying the process of conversion of a chemical substance into a solid from a solution by converting the substance into an insoluble form or a supersaturated solution, known as precipitation causes the antibody to precipitate so that the impurities can be washed away. This is Zydney's new protein purification process that involves adding zinc chloride and polyethylene glycol, a water-soluble polymer, to a solution containing the antibody.

Zydney clarified that the zinc chloride utilized in precipitation is a basic salt, making it a lot less expensive than other sanitization techniques. It likewise saves time, as it is feasible to yield huge amounts of proteins in brief timeframes.

Currently, antibodies are produced using a process called Protein A affinity chromatography, where the antibody binds to Protein A, which is immobilized in a chromatography column. The impurities can be washed away from the bound antibody, after which the pH level is adjusted to recover the purified antibody product. A single Protein A chromatography column can cost more than $10 million.

"If you look at the top 10 best-selling medications, by annual sales, eight are in the category of monoclonal antibodies," Zydney said. "And every year, individuals and insurance companies spend upwards of $100 billion on antibodies, with costs to treat a single patient often exceeding $50,000. There remains a huge unmet need for these products in treating a growing range of diseases."

"That is just one step in the current manufacturing process, and it is what makes antibody manufacturing so expensive," Zydney said. "All of the major biotechnology companies are big players in this space."

"What we do in our research group is relatively small scale," He said. "But the precipitation process has the potential to be easily scaled up, potentially enabling biopharmaceutical companies to produce lower-cost antibodies for the patients who need them."

Todd Przybycien, professor of chemical and biological engineering at Rensselaer Polytechnic Institute, contributed to this research.

The National Science Foundation's Grant Opportunities for Academic Liaison with Industry (GOALI) program upheld this work. As a component of the award, Zydney's exploration bunch teamed up with Boehringer Ingelheim, a significant biopharmaceutical organization that produces antibodies.


Sputnik-V rollout in Delhi, Postponed Once Again!

Treatment Using Genetic Engineering and Light-Activated Therapy has Helped a Blind Man Regain Partial Sight in One Eye

Sanofi S.A. has Agreed to a Pensions Package of Approximately £770 million ($1.1 billion)

French CDMO Yposkesi to Build a Second Commercial Cell and Gene Therapy Plant

Unusable Vaccine Doses at Baltimore Plant Investigated by FDA

Danish government needs to reevaluate dropped antibodies

WHO currently utilizing Greek letters in order for Covid variation names

GP Clinics is now ready to accept COVID-19 Vaccinations for ages over 50

EU Signed a Contract with Pfizer for Almost 1.8 Billion Doses of the Coronavirus Vaccine

Pfizer has gauge $26 billion in Covid-19 antibody deals this year

Hospira, Inc Under Investigation After Reported Mislabeling

Global Access to COVID-19 Vaccines

Moderna Is Testing a New Version of Its COVID-19 Vaccine That Wouldn’t Require Ultra-Cold Storage

No Logical Proof COVID-19 Vaccine Affects Menstruation or Fertility

Full Steam Ahead on Johnson & Johnson and AstraZeneca Vaccines

India Established a Record for Daily Infections Worldwide

Vaccines to Detainees at Guantanamo Bay are now being Offered by the U.S.

Israel's Quick and Effective Vaccine Rollout

J&J Pause a Mere Bump in the U.S. Antibody Rollout?

Stoppage in the Utilization of Johnson and Johnson's Covid-19 Vaccine

Supply Constraints Ease in U.S. Vaccine Rollout

Israel's Vaccine Rollout Curbs Covid-19 Spread

Effects of England's salt reduction Program

The COVID-19 Vaccination Race in Asia

UK and the EU are as yet entangled in an unpleasant disagreement about a deficiency of antibodies across Europe

Progress of COVAX Deliveries

Non-AstraZeneca option for under 30s; E.U. tracks down a 'potential connect' to rare clots

Emergent BioSolutions Threw Out Millions of Doses of Covid-19 Vaccines

Kidney Transplants on the Rise

Vaccine Passports

Coronavirus Briefing: U.S. Economy Bounces Back

India Recorded its Highest Tally of New Coronavirus Infections

Moderna dishes out for CEO security as its COVID-19 immunization gets the spotlight

How soon until the Pfizer antibody is ready for aged 12-15 years old?

Netherlands the Latest Country to Prohibit the Use of AstraZeneca Shot

NHS study finds that CT scan gets 70% of Lung Cancer at the Beginning Phase

How to Apply DQ/IQ/OQ/PQ in New Framework

Design of an Efficient Stability Programme -Bracketing and Matrixing

QP Declaration

Negotiations on Cost and Availability of New Pharmaceuticals

Covid-19 in China - Statistics & Facts

5 Health Care Stocks to Bet on as Coronavirus Woes Linger

Coronavirus Impact on the Tourism Industry Worldwide

Cold chain distribution; route qualification approaches

The v model in validation

GAMP V computer system validation